Tissue engineered aortic valve
نویسنده
چکیده
Several prostheses are available to replace degenerative diseased aortic valves with unique advantages and disadvantages. Bioprotheses show excellent hemodynamic behavior and low risk of thromboembolic complications, but are limited by tissue deterioration. Mechanical heart valves have extended durability, but permanent anticoagulation is mandatory. Tissue engineering created a new generation heart valve, which overcome limitations of biological and mechanical heart valves due to remodelling, regeneration and growth potential. Several publications are available in using tissue engineered heart valves in right ventricular outflow tract reconstruction. Limited experiences are available on these heart valves implanted into the systemic circulation. This overview shows the current state on the development of tissue engineered aortic heart valves.
منابع مشابه
Doppler echocardiographic findings in tissue engineered aortic valve in a sheep model
Background: Heart valve diseases are considered a common disease in human and animals, and valve replacement is an option for treatment of valvular diseases. Objectives: In this study efficacy of a tissue engineered valve in thoracic aorta was evaluated with transthoracic echocardiography. Methods: This study was undertaken on 6 male sheep. Echocardiography was performed on all sheep 24 hours b...
متن کاملAutologous human tissue-engineered heart valves: prospects for systemic application.
BACKGROUND Tissue engineering represents a promising approach for the development of living heart valve replacements. In vivo animal studies of tissue-engineered autologous heart valves have focused on pulmonary valve replacements, leaving the challenge to tissue engineer heart valves suitable for systemic application using human cells. METHODS AND RESULTS Tissue-engineered human heart valves...
متن کاملPlanar biaxial behavior of fibrin-based tissue-engineered heart valve leaflets.
To design more effective tissue-engineered heart valve replacements, the replacement tissue may need to mimic the biaxial stress-strain behavior of native heart valve tissue. This study characterized the planar biaxial properties of tissue-engineered valve leaflets and native aortic valve leaflets. Fibrin-based valve equivalent (VE) and porcine aortic valve (PAV) leaflets were subjected to incr...
متن کاملFunctional tissue engineering of the aortic heart valve.
INTRODUCTION Aortic heart valve dysfunction is commonly treated with replacement of the valve. To overcome the shortcomings of currently used mechanical valves, xenografts and homografts, efforts are being made to create fully autologous heart valve replacements using the concepts of tissue engineering. To this end autologous cells are seeded onto pre-shaped biodegradable scaffolds and cultured...
متن کاملHypoxia induces near-native mechanical properties in engineered heart valve tissue.
BACKGROUND Previous attempts in heart valve tissue engineering (TE) failed to produce autologous valve replacements with native-like mechanical behavior to allow for systemic pressure applications. Because hypoxia and insulin are known to promote protein synthesis by adaptive cellular responses, a physiologically relevant oxygen tension and insulin supplements were applied to the growing heart ...
متن کامل